Friday, February 15, 2008

Lidocaine NMR Samples

The latest spectra are now posted online.  The lidocaine specs look pretty good!!  The final product, lidocaine bisulfate, is not very soluble in CDCl3, which is why some of you may have observed cloudy NMR sample solutions.  The book uses dimethyl sulfoxide (DMSO) for the NMR sample, which is much more polar and better able to dissolve your final product.  We don't have any DMSO currently, so CDCl3 will have to do; Navid's spectra turned out great in CDCl3 anyway.  Just be aware that the chemical shift values (ppm) for each proton signal will be slightly different than those reported in your textbook since chemical shift is solvent dependent.

No comments:

Post a Comment